The Strange Case of the End of Civilization as We Know It 1977 Synopsis - John Cleese is hilarious as the descendant of Sherlock Holmes in this modern detective drama of international power politics and intrigue. Unlike his illustrious grandfather however, he only succeeds in bungling every job he organizes. Also stars Arthur Lowe as the "bionic" grandson of Dr. Watson, Stratford Johns as the Commissioner of Police, and Connie Booth as Mrs. Hudson.